I have just installed lubuntu 21.10 from usb-stick and have a complete clean system. And then I installed thunderbird via apt. Everything went well so far.
But thunderbird could not start and an error message appeared: Your Thunderbird profile cannot be loaded. It may be missing or inaccessible.
I can see .thunderbird folder at my home directory. Even deleting this folder will not help.
You had installed the OS using username “lubuntu” ?
/home is named “lubuntu” when starting using USB drive.
Before trying use Thunderbird you need figure if the /home/ folder is using your user name.
When you start using USB driver Lubuntu Installation is used lubuntu for home.
Yes try install not using lubuntu.
The issues in your post not look being problem with Thunderbird.